Techniques for Assessing Teratogenic Effects: Epidemiology
نویسندگان
چکیده
منابع مشابه
Techniques for assessing teratogenic effects: epidemiology.
Epidemiologic studies of malformations can aid in the understanding of human teratogenesis. Employing a variety of approaches epidemiology can develop or test hypotheses concerning possible causes or through surveillance provide data useful for a variety of purposes. Drawing heavily upon our experiences at the Center for Disease Control, this paper reviews some concepts and uses of epidemiology...
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pidemiological studies of pregnancy outcomes of women with epilepsy are important, primarily to inform choice of treatment options in clinical care of pregnant women and to inform counselling, the need for prenatal and postnatal screening, and the need for early medical, behavioural, or educational intervention. In this issue (page 251), Dean et al report on a long term follow up of the health ...
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Most studies designed for assessing teratogenic effects focus on only three of four types of final manifestations of abnormal development; namely intrauterine death, malformations, and growth retardation. Developmental toxicity evaluations generally do not include functional deficits. Current techniques are inadequate for assessing functional capability during perinatal development, and there i...
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The use of older generation antiepileptic drugs (AEDs) during pregnancy is known to be associated with a two- to threefold increased risk of birth defects in the offspring and possible also other adverse outcomes in the exposed infant. Much less has been known about newer generation AEDs in this respect. Recent studies based on national registries as well as specific epilepsy and pregnancy regi...
متن کاملTeratogenic effects of antiepileptic medications.
Data on clinical teratogenicity are at best derived from carefully conducted observational studies, whereas randomized, controlled trials have no place in this research area. We can only expect level B recommendations and lower. New relevant information has become available during the last 5 years on pregnancy outcomes with 3 of the most frequently used AEDs: carbamazepine, valproate, and lamot...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1976
ISSN: 0091-6765
DOI: 10.2307/3428693